The ABCG5/8 (encoding the hepatobiliary cholesterol transporter 5/8) allele is interrelated with the recurrence of choledocholithiasis, and its variant gene ABCG D19H is currently recognized as a genetic risk factor for the formation of gallstones, which can effectively predict the recurrence of choledocholithiasis.89 The gene discussed is ABCG5; the disease is choledocholithiasis.