From the above studies in different systems, we could discover that autophagy-related diseases induced by PM2.5 are mainly involved in inflammation-related signaling pathways, including β2AR/PI3K/Akt, caspase3/JNK/P53, COX-2/PGES/PGE2, ROS-JNK/ERK, MAPK/NF-кB/STAT1 (Figure 1). This evidence concerns the gene MAPK8 and glycogen storage disease VI.