SPRYD4 and hepatocellular carcinoma: In addition, a total of 20 target genes including ABAT, ADRA2B, ANGPT4, CD69, CHEK1, FGA, KIF18B, MMAA, NDST3, PANK1, PDE2A, PNPLA7, PPARGC1A, RAD54B, SERPINF2, SLC38A4, SPRYD4, SRD5A1, SYNPO2, ZNF391 were significantly related with OS of HCC patient using Kaplan-Meier method (Figure 9).