Recent research has demonstrated that a local RAS is present within healthy skin and plays a vital role in wound repair and tissue reconstruction through Ang II 14, 15, which stimulates proliferation, migration, and matrix production of human dermal fibroblasts 16, 17, as well as in keloid pathogenesis via the activation of angiotensin type 1 receptor (AT1)-dependent signaling pathway 18. The gene discussed is AGT; the disease is keloid.