RNASE2 and neoplasm: Through regulating the expression of MGMT and MLH1, RPL22L1 can affect tumor progression and chemotherapeutic drug resistance 23 RNASE2 and RNASE3 are mainly involved in human immune function, and RNASE2 plays an important role in sensing of pathogens by toll-like receptor 8 (TL8) 24.