Additionally, via univariate Cox regression analysis, survival analyses, and multiple Cox regression analysis, we identified eight hub RBPs (RPL22L1, RNASE2, RNASE3, EZH2, DDX25, DQX1, EXOSC5, DDX47) and built a risk model to predict prognosis of RCC. This evidence concerns the gene DDX25 and renal cell carcinoma.