COVID-19 patients were divided into a moderate cohort and a severe cohort, and we identified that neutrophil percentages > 70%, neutrophil counts > 6.3 × 109/L, lymphocyte percentages < 20%, NPR > 2.3, NLR > 3.9, albumin < 40 g/L, and LDH > 245U/L might be risk factors for disease severity among COVID-19 pneumonia patients. This evidence concerns the gene ALB and COVID-19.