Some studies have shown that under the regulation of pregnancy-related molecules, the level of adiponectin in pregnancy is significantly higher than in non-pregnancy, while female patients with overweight or PCOS show generally a lower level of adiponectin than normal women [26], and they are more likely to suffer from metabolic diseases, such as gestational diabetes mellitus, during pregnancy [27, 28]. This evidence concerns the gene ADIPOQ and Other metabolic disease.