PTGS2 and polycystic ovary syndrome: On the one hand, low-dose androgen exposure can enhance the expression of steroidogenic acute regulatory protein (StAR) and peroxisome proliferator-activated receptors γ (PPARγ), which regulate the utilization of cholesterol, showing an antioxidant response in PCOS offspring; on the other hand, high-dose androgen exposure can induce a pro-inflammatory state in ovarian tissue mediated by a high prostaglandin level and the expression of cyclooxygenase-2 protein (COX2).