Furthermore, the NADPH/NADP+ ratio and the glutathione (GSH)/oxidized glutathione (GSSG) ratio were all increased in Sun‐R cells, with Sirt5 knockdown decreasing the levels of these ratios, showing that modulation of Sirt5 levels significantly influenced the antioxidant capacity of RCC cells (Fig. 3D). The gene discussed is SIRT5; the disease is renal cell carcinoma.