Recent whole‐exome and/or whole‐genome sequencing analyses of pancreatic cancer have revealed that KRAS (65%–95%), TP53 (33%–66%), SMAD4 (16%–23%), and CDKN2A (19%–20%) were the most frequently altered genes, followed by TTN (12%–16%).4, 5, 14, 15. Here, SMAD4 is linked to familial pancreatic carcinoma.