50-year-old woman had right femoral pain. Examination showed left breast tumor and multiple lytic lesions including right femoral bone. She was diagnosed as breast cancer (ER positive/PR positive/Her-2 negative/Ki-67 5%) and multiple BMs. Internal fixation was performed for right femoral BM due to the impending fracture. She now has a little pain. Her ECOG PS is 2. The gene discussed is MKI67; the disease is breast carcinoma.