Addition to CTCF and cohesin, Brother of The Regulator of Imprinted Sites (BORIS, also known as CTCFL) is an emerging architectural protein, which is a paralog of CTCF and typically expressed in testis and ESCs (Loukinov et al., 2002) but aberrantly overexpressed in several cancers (D’Arcy et al., 2008; Bhan et al., 2011; Link et al., 2013; Cheema et al., 2014). The gene discussed is CTCF; the disease is cancer.