Moreover, ApoE and Triggering Receptor Expressed On Myeloid Cells 2 (TREM2), the most well-known risk factors for sporadic AD, are highly associated with tau-mediated pathology, deteriorating tau-induced neurotoxicity in a mouse model of tauopathy [11], and worsening gliosis and inflammation related to tau-mediated neuronal damage [12, 13]. Here, MAPT is linked to tauopathy.