On the basis of previous findings supporting E-cadherin as an oncogene in IBC3,8,18–21 and our own findings supporting a possible association of DCN and inhibition of E-cadherin and EGFR activation, we speculated that DCN may suppress invasion and tumor growth in IBC via inhibition of EGFR signaling, which is dependent on E-cadherin for its regulatory function. Here, EGFR is linked to inflammatory breast carcinoma.