CDH1 and invasive lobular breast carcinoma: These findings are also consistent with clinical data showing that E-cadherin-negative invasive lobular carcinoma cells remain intrinsically epithelial with limited evidence of EMT features56 and that E-cadherin loss was insufficient to induce classical EMT in a murine invasive lobular carcinoma model established by conditional mutation of CDH1 and knockout of TP5357.