In the present cohort, 47% of the syndromic IRD index cases (270/577) suffered from USH2, followed by 17% USH1 (98/577), as well as other very rare syndromes like some atypical forms of Usher syndrome (3%; 16/577) and ciliopathies such as BBS or ALMS (16%; 90/577). This evidence concerns the gene USH2A and ciliopathy.