We here report an expanded characterization of gene expression in KIS-1 cells, confirm the lack of CD19 expression and demonstrate reduced expression of other B cell hallmark genes including CD79b and EBF1. Exogenous expression of the transcription factor EBF1, a transcription factor required for the expression of certain PAX5-regulated genes14, is sufficient to restore expression of CD19, CD79b and other B cell-specific genes to KIS-1 DLBCL cells. Here, EBF1 is linked to diffuse large B-cell lymphoma.