1317 of the 1557 down-regulated genes in KIS-1 were mapped using DAVID 2.015 to five KEGG pathways with a fold enrichment of at least 2.5: Primary immunodeficiency (hsa05340), Osteoclast differentiation (hsa04380), B cell receptor signaling pathway (hsa04662), Arginine and proline metabolism (hsa00330), and NF-κB signaling pathway (hsa04064). This evidence concerns the gene NFKB1 and inborn error of immunity.