This would fit with the proposed flexibility in globin-chain expression observed by Kobari et al., who have reported that SCD-iPSC derived erythroid progenitor cells that in vitro express fetal hemoglobin (HbF) will convert to adult beta globin (HbA) expression containing the mutated adult beta sickle cell HBS peak in HPLC upon injecting in vivo, revert to producing beta-globin expressing erythrocytes upon injection into NOD-SCID mice7. The gene discussed is HBB; the disease is Schnyder corneal dystrophy.