Consistent with the up-regulation of SSTR expression in SCLC (Fig. 5c and Supplementary Fig. 27), we also observed significant hypomethylation of the promoter regions of SSTR1, SSTR2, and SSTR5 in SCLC, but only when using the CHALM method (Fig. 5d and Supplementary Fig. 28). Here, SSTR2 is linked to small cell lung carcinoma.