Herein, the same core circadian clock genes that are rhythmically controlled by CRY1 in osteosarcoma cells are also bound by CRY1 in PCa (i.e., CRY1, CRY2, PER2, and PER3) (Fig. 2a) showing concordance of binding across models regardless of circadian synchronization. The gene discussed is CRY1; the disease is osteosarcoma.