Interestingly, even when adjusting for age, high CRY1 remained an independent prognostic variable (HR 1.56 with a 95% CI [1.04–2.34], p = 0.029] (Fig. 1d), further strengthening the importance of CRY1 functioning as a protumorigenic factor in PCa. The gene discussed is CRY1; the disease is posterior cortical atrophy.