SP2 and cancer: In addition to motifs for NPAS (a factor known to interact with CRY1)10,23, multiple motifs of PCa relevance were enriched proximal to CRY1 binding, including several factors elevated in PCa, linked with androgen-associated cancer growth, and involved in the epithelial-mesenchymal transition and cancer progression (e.g., FOXD2, SP2)24–27.