Herein, the same core circadian clock genes that are rhythmically controlled by CRY1 in osteosarcoma cells are also bound by CRY1 in PCa (i.e., CRY1, CRY2, PER2, and PER3) (Fig. 2a) showing concordance of binding across models regardless of circadian synchronization. This evidence concerns the gene PER2 and osteosarcoma.