Given the clinical observations that CRY1 is upregulated in PCa and associated with poor outcome (Fig. 1), combined with molecular observations that the protein induces gene networks of importance for DNA repair (Figs. 2, 3) and is stabilized after DNA damage (Fig. 4), computational strategies were employed to integrate cistrome and transcriptome analyses, with the goal of identifying the mechanism(s) of action by which CRY1 modulates the response to DNA damage. The gene discussed is CRY1; the disease is posterior cortical atrophy.