While CRY1 somatic alterations and gene amplifications occur in several tumor types, (Supplementary Fig. 1c), CRY1 is frequently amplified in PCa and CRPC (Supplementary Fig. 1c–e) to a similar frequency of AR and key target genes (KLK3, FKBP5) previously known to be amplified in PCa (Supplementary Fig. 1f). Here, FKBP5 is linked to posterior cortical atrophy.