Six months of treatment resulted in (1) a significant reduction in NT-pro-BNP levels (2) a subtle improvement in systemic RV function as assessed by echocardiography and (3) improvement in the 6 min walking distance and health-related QOL, without high rates of treatment discontinuation, symptomatic hypotension, hyperkalaemia or renal function decline. Here, NPPB is linked to Hyperkalemia.