We previously reported that abnormally elevated MTL (entorhinal cortex, EC) tau PET was evident in PSEN1 E280A carriers relative to non-carriers from the Colombian kindred as early as 6 years prior to expected onset of mild cognitive impairment (MCI), and the overall spatial pattern of tau PET in ADAD was similar to that seen in sporadic AD [18]. The gene discussed is MAPT; the disease is Cognitive impairment.