Findings from tau PET studies of sporadic AD have been consistent with the spatiotemporal progression of tauopathy implied by postmortem studies [17]; namely, that cortical tau accumulation begins focally in medial temporal lobe (MTL) allocortex and later spreads to temporal and extratemporal neocortex (also called “isocortex”) in association with Aβ [12, 13]. The gene discussed is MAPT; the disease is Alzheimer disease.