In previously reported longitudinal PET data from our group processed with the same pipeline reported herein [15], sporadic AD patients showed rates of tau change in precuneus (mean ± SD [range]) of 0.091 ± 0.157 [− 0.057 0.448] SUVR/year, or on average 3.7% per year. This evidence concerns the gene MAPT and Alzheimer disease.