The rates of neocortical tau increase we observed here (PC mean: 0.16 SUVR/year, 9%/year; max: 0.46 SUVR/year, 28%/year) were markedly higher than has been reported in sporadic AD (~ 0.05 SUVR/year, 3–6%/year) [20–22], although one study of sporadic AD reported rates as high as 8%/year tau PET increase in Braak V (including precuneus) [24]. Here, MAPT is linked to Alzheimer disease.