Thus, there was a 13% elevation of endotoxin LPS (Fig. 4c; F(1, 29): 8.43, p = 0.007) and a 3.5-fold elevation of Muc-2 (Fig. 4d; F(1, 29): 25.97, p < 0.0001) in males as compared to females, irrespective of stroke, indicating a low-grade gut leakiness in males may predispose systemic inflammation and worsen stroke outcomes. Here, MUC2 is linked to stroke disorder.