XPO1 and B-cell chronic lymphocytic leukemia: As virtually all samples harboring mutated XPO1 had either unmutated IgHV or LP-CLL, we next examined this data for clinical features associated with mutated XPO1 that could distinguish such patients from patients with CLL cells that did not have XPO1 mutations but using unmutated IgHV or present an LP-CLL epigenetic signature (Table 1).