Ingenuity Pathway Analysis (IPA) of these differentially expressed genes in XPO1-E571K CLL cells confirmed an enrichment for T cell-specific signaling pathways, including T cell activation and regulation, autoimmunity, NFAT signaling, NF-κB activation, and Tec kinase signaling (Fig. 1f). This evidence concerns the gene XPO1 and B-cell chronic lymphocytic leukemia.