Large scale longitudinal evaluation of Eμ-XPO1 transgenic colonies resulted in similar overall survival between Eμ-XPO1 and C57BL/6 non-transgenic colonies, with both Eμ-XPO1 colony and C57BL/6 non-transgenic survival times extending significantly past the median survival observed in Eμ-TCL1 CLL model (Fig. 2b). The gene discussed is XPO1; the disease is B-cell chronic lymphocytic leukemia.