Significant downregulation of a select few genes were noted in CLL cells with XPO1-E571K compared to those with wt XPO1, including KLK2, BEND3, and WNT3. Interestingly, CLL cells with XPO1-E571K displayed significant upregulation of several genes expressed in activated T lymphocytes, including ITK, CCL5, CCR5, CD2, CD28, CD96, CD226, and TRBC1, among others. This evidence concerns the gene CD2 and B-cell chronic lymphocytic leukemia.