XPO1 and B-cell chronic lymphocytic leukemia: On the other hand, whereas nearly 16–18% of samples with wt XPO1 and unmutated IgHV or LP-CLL had trisomy 12 (+ 12) at diagnosis, none of the samples with mutated XPO1 had this chromosomal abnormality (p = 0.011, p = 0.006, respectively).