Roughly 70% of evaluable XPO1-mutated patients presented del(13q14) as a co-occurring genetic abnormality, a significant increase from the ~ 50% reported in the general CLL population and the ~ 42–45% reported in CLL cells with wt XPO1. Despite a historically fair prognosis, the survival outcomes of these patients were among the shortest reported in this study, suggesting some combination of dysfunctional molecular signaling stemming from these genetic aberrations are acutely advantageous for proliferation of the CLL cells. Here, XPO1 is linked to B-cell chronic lymphocytic leukemia.