In a recent trial of anifrolumab, an anti-IFN-α receptor antibody that blocks the activity of IFN-α, IFN-β, and IFN-ω, approximately twice as many SLE patients achieved a low disease activity state at week 52 following initiation of treatment as compared to placebo control [32]. This evidence concerns the gene IFNB1 and systemic lupus erythematosus.