To validate whether exosomal miR-9-5p mediated the resistance by the regulation of ADIPOQ expression, we delivered the miR-9-5p mimic and inhibitor into the isolated exosomes from the MCF-7 and MCF-7/TAM cells followed by co-culture with the MCF-7 cells, in order to verify whether exosomes affect BC cells by carrying miR-9-5p. The gene discussed is ADIPOQ; the disease is breast cancer.