Overall, we can conclude that after FOLFOX stimulation, internalized CD44v6 complexes with YB-1, and the combined signaling complex reaches the nucleus, where CD44v6 regulated YB-1 stimulates promoters for the MDR1 and CD44v6 genes, which sustains FOLFOX resistance and tumor formation through CD44v6 overexpressing CICs. This evidence concerns the gene YBX1 and neoplasm.