LGR5 and colorectal carcinoma: The promoter sequences associated with TFs (Supplemental Table S2) that bound to the CD44v6 protein could be classified into two themes: (1) genes for 5-motifs such as, Cyclin D1 for cell proliferation/apoptosis-resistance/stemness [115], BCL2 for cell survival [115], FZD1 for stemness [116,117], GINS-1 for DNA replication modulation to regulate proliferation in CICs [118], and MMP9 for cell invasion [119]; (2) four core-stemness genes (ALDH1, NANOG, Lgr5 and ABCB1) for drug-resistance and maintenance of stemness of CRC CICs [115].