Its role in CRC progression derives from its ability to bind ligands associated with both tyrosine kinase receptors or non-tyrosine kinase receptors including c-Met, VEGF, TGFβ1, and ERB2 [48,49,50,51,52,53,54,55,56,57,58], leading to changes in biological activities such as activation of antiapoptotic signaling, cell-matrix adhesion, cell migration, proliferation, differentiation, and survival [59,60]. This evidence concerns the gene TGFB1 and colorectal carcinoma.