CRC CICs exhibit characteristics comparable to normal stem cells that could be associated with the expression of similar TFs including SOX2, OCT4, NANOG, KLF4, Lgr5, TWIST1, and c-Myc, and signaling pathways including WNT/β-catenin pathways directed for CRC propagation [65,84,85]. This evidence concerns the gene KLF4 and colorectal carcinoma.