Given that shRNA suppression of CD44v6 protein significantly blocked the FOLFOX-induced YB-1 (Figure 1D), and that the involvement of CD44/CD44v6 in regulating COX2 derived PGE2 production [50,102], which in turn regulates YB-1 in other cancer cell types [111], we investigated a possible interconnection between FOLFOX induced CD44v6-PGE2 signaling and YB-1. This evidence concerns the gene YBX1 and cancer.