Furthermore, in a passive model of EAE, adoptive transfer (direct injection of ex vivo activated immune cells) of CNTN2-specific CD4+ T cells induced gray matter inflammation in rats [101] to a bigger extent than in the MOG-EAE model, suggesting a specific role for autoimmunity against CNTN2 in gray matter inflammation and damage. Here, CNTN2 is linked to Autoimmunity.