Saric et al. identified AhR as a potent tumor suppressor in a SHH medulloblastoma mouse model by controlling the TGFβ/SMAD3 signaling axis to inhibit proliferation and promote the differentiation of cancer-propagating cells (CPCs) (reservoir of cells capable of tumor regeneration and relapse post-treatment) [58]. The gene discussed is SMAD3; the disease is medulloblastoma.