Members of MPs show different patterns of spatial and temporal upregulation during cardiac remodeling, such as TSP-1 in myocardial infarction, ventricular hypertrophy, and cardiac dilation, TSP-4 in ventricular hypertrophy and myocardial injury, and Tenascin C in tissue injury and fibrosis [21,22,23,24,25,26,27]. This evidence concerns the gene THBS4 and cardiac hypertrophy.