In this study, a classic Hodgkin’s lymphoma cell line (KMH2) and two non-Hodgkin’s lymphoma cell lines, an activated B-cell diffuse large B-cell lymphoma (ABC-DLBCL) cell line (SUDHL2) and a germinal centre B-cell diffuse large B-cell lymphoma (GCB-DLBCL) cell line (SUDHL4), will be used as a model to assess the anticancer activity of [Au(d2pype)2]Cl and investigate the Trx and GSH systems’ response after treatment with [Au(d2pype)2]Cl. Here, TXN is linked to diffuse large B-cell lymphoma.