Specifically, amplifications of FGFR1 gene have been found in 9–10% of urothelial BC, followed by FGFR3 (3–5%) and FGFR2 (0.8%), and activating mutations of FGFR3 gene have been described in 38–66% of non-invasive BC and 15–20% of invasive BC. The gene discussed is FGFR2; the disease is breast cancer.