MiR-125b is an essential modulator of cancer tumorigenesis, being involved in macrophage activation and the modulation of various oncogenic pathways, including NF-κB, p53 and PI3K/Akt/mTOR, having significant roles in modulating the essential cancer pathways, including proliferation, apoptosis, metastasis and drug resistance [128]. The gene discussed is NFKB1; the disease is cancer.