In the last decade, several emerged biomarkers, such as serum carcino-embryonic antigen (CEA) [7], carbohydrate antigens (CA) 13-5, CA27-29 [8], BRCA1/2 genes [9] circulating tumor cells (CTCs) [10], tumor infiltrating lymphocytes (TILs), etc., have shown to be useful in prognosis, monitoring treatment response, prediction of progression and survival. This evidence concerns the gene CEACAM5 and neoplasm.