ANGPTL3 KO in liver-derived cell lines, caused intracellular ApoB accumulation [64] and a change in intracellular lipidic content, towards longer and more unsaturated fatty acid chain as poly-unsaturated fatty acid (PUFA), which may be protective towards NAFLD and NASH [62,64]. This evidence concerns the gene ANGPTL3 and metabolic dysfunction-associated steatotic liver disease.