ANGPTL3 and familial hypobetalipoproteinemia 2: As a consequence, ANGPTL3 deficiency leads to an important reduction in circulating lipids, namely cholesterol, TGs, and HDL-C as described in Sun KK, a mouse KO-ANGPTL3 model, as well as in subjects affected by familial hypobetalipoproteinemia type 2 (FHBL2) [OMIM #60519], the human model of ANGPTL3 deficiency [54,57,59,62,63,64].