To further highlight the role of ANGPTLs as mediators of unhealthy adipose tissue expansion, it may be relevant to examine changes in the ANGPTL3-4-8 system in pathological conditions in which adipocytes play a pivotal role, namely T2DM/insulin-resistant state, NAFLD/NASH, and lipodystrophies (Table 1). The gene discussed is ANGPTL3; the disease is metabolic dysfunction-associated steatotic liver disease.