OPTN and amyotrophic lateral sclerosis: The ablation of genes involved in autophagy is enough to trigger neurodegeneration in murine models [68,69] and, as it is described above, multiple ALS-related genes are directly involved in mitophagy pathways such as OPTN, TBK1, or SQSTM1. Therefore, many autophagy-stimulating drugs have been probed in ALS models and studied to determine their pharmacological action.