TFF2 and obesity due to melanocortin 4 receptor deficiency: Indeed, it fits, for instance, with the hypothesis linking a high-fat diet with trefoil factor 2 (TFF2) as a lipid-induced signal for which the corresponding gene (Tff2) is induced by the high-fat diet [27], whereas its knockout provides protection from obesity [28] by leading to an antiobesity metabolic phenotype [29].