FAAH and major depressive disorder: Rodent studies suggest beneficial effects of ECB signaling enhancers such as the FAAH inhibitor URB597 (URB; FAAH degrades AEA), the CB1/2 receptor agonist WIN55,212-2 (WIN), and cannabidiol (CBD; a cannabis sativa constituent) in rodent models for depression [15,80,81,82], anxiety, and PTSD [16,83,84,85,86].