Koller et al. found that IL-4Rα–the subunit of type II IL-4R in epithelial cells (Figure 1)–expression promoted tumor growth in human CC cell lines HCT116, HT-29, DLD-1, SW480, SW620, Caco2, and HCA7, while IL-4 could only decrease apoptosis in HCT116 cells [68]. Here, IL4R is linked to neoplasm.