Similarly to the survival of EGFR-mutant NSCLC cells (Figure 1), lysine deprivation consistently reduced the survival of the three resistant cell lines (Figure 2C–E; red bars), and NCI-H1975 cells harboring exon-16-skipping human epidermal growth factor receptor 2 (HER2) (Figure S6) which, based on results from our recent study, is known to be an osimertinib-resistant cell line [25]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.