EGFR and non-small cell lung carcinoma: We examined the genes involved in lysine catabolism, including the saccharopine and pipecolate pathways, and found that the expression of AADAT consistently increased in response to lysine deprivation in all EGFR-mutant NSCLC cells, and that this occurred alongside the induction of phosphor-AKT for survival in EGFR-mutant NSCLC cells.