Ceramide synthase 6 and C16-ceramide levels are higher in acute lymphoblastic leukemia cells compared to peripheral blood mononuclear cells and T lymphocytes derived from healthy human volunteers and it has been demonstrated that ceramide synthase 6 interferes with Fas-associated protein with death domain, death-inducing signaling complex (FADD DISC). The gene discussed is CERS6; the disease is acute lymphoblastic leukemia.