A phase II clinical trial was performed in NB patients subjected to multiple cycles of induction chemotherapy with different drugs (including cyclophosphamide, topotecan, cisplatin, etoposide, doxorubicin and vincristine) and infused with the anti-GD2 Ab hu14.18K322A with GM-CSF and IL-2 [83]. The gene discussed is IL2; the disease is neuroblastoma.