Basket trials mostly investigate less conventional target, such as EpCAM in EpCAM positive cancer (HCC, gastro-intestinal cancer, liver cancer) (NCT03013712) or Claudin18.2, a protein implied in tight junctions and expressed in digestive tumors (stomach, gastroesophageal junction, pancreas, and liver) (NCT03302403). The gene discussed is EPCAM; the disease is hepatocellular carcinoma.