ZNF750 (zinc finger protein 750) which is described as a tumor suppressor gene in squamous cell carcinoma [110,111], is as well subject to high positive selection (dN/dS ratio > 50) in regions of LOH in lung squamous cell carcinoma (LUSC) and head and neck squamous cell carcinoma (HNSC) [104]. The gene discussed is ZNF750; the disease is squamous cell carcinoma.