Notably, they further expanded the analysis to the remaining cancer subtypes in TCGA and 33 potential tumor suppressor genes were identified by limiting the analyses to sections of LOH and 14 additional novel genes (WWC1, FPF12, NT5DC3,NCLN, KRTAP195, GRIK2, GLRA1, FAXDC2, FAM19A3, CRYGC, CLEC4E, BC02, ARPP21 and AC061992.1) were discovered which were assumed tumor suppressor genes but not included in the catalogue of somatic mutations in cancer (COSMIC) [112]. The gene discussed is CLEC4E; the disease is cancer.