In a recent study of 90 patients with biopsy proven primary PCa, PSA-value and GG correlated with the intensity of tracer expression on 68Ga-PSMA-11 PET/CT, with a significantly higher tumor-related tracer uptake seen in patients with either PSA ≥ 10 ng/mL or GG ≥ 4 [44]. Here, KLK3 is linked to posterior cortical atrophy.