The mean BS positivity rate among 23 studies that included only newly diagnosed PCa patients without previous treatment, was 2.3% in patients with a PSA < 10 ng/mL, 5.3% in patients with PSA 10 < 20 ng/mL, and 16.2% in patients with a PSA 20 < 50 ng/mL [14]. This evidence concerns the gene KLK3 and posterior cortical atrophy.