Taken together, this study indicates that the upregulation of chemerin, TRAIL, and p53 as well as the downregulation of nexin by mechanical loading contributes to Lrp5-dependent and independent mechanisms by downregulating Lrp5, MMP2, MMP3, MMP9, Runx2, Snail, and TGFβ in tumor cells. Here, LRP5 is linked to neoplasm.