SERPINE2 and Familial prostate cancer: It is reported that chemerin suppresses hepatocellular carcinoma metastasis, breast cancer growth, prostate cancer progression, skin carcinogenesis, and melanoma [36,37,38,39,40], while nexin is a stimulator of peritoneal metastasis in ovarian cancer [41], as well as the growth, migration, and invasion of breast cancer cells [42].