ESR1 and neoplasm: Taking tumor stages and age groups into consideration, the ER-negative patients exhibited lower or a tendency of lower 5-year survival rates than ER-positive patients in all stages and age groups in both datasets, except the ER-negative patients aged ≥ 70 years in TCGA which showed a tendency of a higher 5-year survival rate (Figures S1 and S2; Table S1).