Cells showed full tumorigenic potential as transplantation of Dnmt3a+/- lymphoma cells induced peripheral T-cell lymphoma (PTCL) within 2 months in sublethally irradiated wild-type FVB recipient mice and while the same effect could be also observed upon subsequent transplantation of cells from tumors developed in recipient mice (Fig. 1, F and G). This evidence concerns the gene DNMT3A and peripheral T-cell lymphoma, not otherwise specified.