DNMT3A and lymphoma: Interestingly, these loci were even more hypomethylated in Dnmt3bΔ/Δ; Dnmt3a+/−, and Dnmt3aΔ/Δ lymphomas we derived in our previous studies (26, 31, 39) further suggesting interplay between Dnmt3b and Dnmt3a in their methylation functions (Fig. 5F).