Studies in mice showed that Dnmt3b is a tumor suppressor (TS) in an oncogene-induced hematologic malignancies including T- and B-cell lymphomas induced by MYC and acute myeloid leukemia induced by MLL-AF9 (26, 31, 32, 33, 34). This evidence concerns the gene DNMT3B and B-cell non-Hodgkin lymphoma.