MYC and lymphoma: All lymphomas showed reduction in methylation relative to thymocytes with the highest percentage of hypomethylated DMCs (≥30% change in methylation as analyzed by Metilene based on average of two samples) present in MYC;Dnmt3bΔ/Δ lymphomas (21.1%) and the lowest in Dnmt3b+/− PTCL (9.6%) (Fig. 8, A and B).