MYC and lymphoma: Total number of hypomethylated DMRs was similar between MYC;Dnmt3b+/+ and MYC;Dnmt3bCI/CI lymphomas (∼23,000) suggesting that Dnmt3bCI protein restored at least some Dnmt3b functions lost in MYC;Dnmt3bΔ/Δ lymphomas (Fig. 8C).