Moreover, the enforced hepatic coexpression of serpin E1 with Δ(90) + YAPS127A + serpin E1, while not influencing tumor growth rates, was associated with widespread tumor parenchymal necrosis (https://www.biorxiv.org/content/10.1101/2020.09.13.295311v1). Here, SERPINE1 is linked to neoplasm.