Finally, this technology was applied to staple an α‐helical p53 derived peptide that binds to MDM2, an important cancer target.[16] One stapled peptide was demonstrated to be an efficient inhibitor of MDM2 with a Kd of 29±4 nM showing a 12 times increase of potency compared to the linear peptide, emphasizing the substantial effect of the enhanced helicity. Here, MDM2 is linked to cancer.