In the present study, insulin increased HDL-C (24.84%) and reduced other lipid parameters (TC:18.63%, TG:27.97%, AIP:28.6%); and the values were significantly less (TC:p<0.01, TG:p<0.05, AIP:p<0.001) and HDL-C was significantly more (p<0.001) compared to DN rats with no treatment. This evidence concerns the gene INS and autoimmune pancreatitis.