IGLL5 and AL amyloidosis: Only a limited number of research has shown that IGLL5 has a frequent mutation in chronic lymphocytic leukemia [33, 34], lymphoma [35, 36, 37], and multiple myeloma [38, 39]; besides, IGLL5 has a prognostic value in several diseases, such as multiple myeloma and glioblastoma [39, 40, 41].